Antiphospholipid Syndrome (Diagnosis)

Antiphospholipid syndrome (APS) is a pathological condition in which the immune system attacks the phospholipids of its own cells. This often leads to the development of obstetric pathology (adverse pregnancy outcomes, intrauterine fetal death, etc.), thrombosis, thrombocytopenia and other serious disorders.

To diagnose APS,

MedLab uses a set of tests aimed at identifying the causes of this pathology:

1. Genetic testing – performed once to determine the risk of thrombocytopathy and hyperhomocysteinemia (Genes GE5,6,7 and GE8,9,10,11, respectively);

2. ELISA diagnostics for immunology:

antiphospholipid antibodies – a screening test for miscarriage / pregnancy pathologies, a history of thrombosis – determines the total level of antibodies to phospholipids;
antibodies to cardiolipin – the risk of thrombosis and thrombocytopenia https://en.wikipedia.org/wiki/Thrombocytopenia, the level increases immediately before the development of thrombosis;
antibodies to b2-glycoprotein – the risk of thrombosis, thrombocytopenia and obstetric pathologies;
antibodies to annexin – the risk of thrombosis, miscarriage, failure of in vitro fertilization;
antibodies to prothrombin – the risk of microcirculation disorders, implantation defects and placental pathology during pregnancy.
3. Coagulogy: Lupus anticoagulant (screening and confirmatory tests) – risk of thrombosis and miscarriage.